STC2 promotes colorectal cancer progression via c-Myc-mediated glycolysis and the PI3K/AKT/mTOR pathway

20260 citationsJournal Articlegold Open Access

Authors

Jun Jiang · Fudan University

Xiaohong Zhang · Fudan University

Fangzhou Ye · Fudan University

Peiyu Qian · Fudan University

Fan Li · Fudan University

Huanqing Li · Obstetrics and Gynecology Hospital of Fudan University

Li Feng · Fudan University

Abstract

These findings highlight STC2 as a key regulator of CRC progression, which regulates c-Myc-driven glycolysis through the PI3K/AKT/mTOR pathway. Targeting STC2 or its downstream metabolic effectors may provide new therapeutic strategies for CRC management.

Topics & Keywords

PI3K/AKT/mTOR signaling in cancer Colorectal Cancer Treatments and Studies Cancer, Hypoxia, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Discover Oncology

DOI: 10.1007/s12672-026-04733-7

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