SCW: building the whole-genome 3D structures based on extremely sparse single-cell Hi-C data

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Abstract

SCW enables high-precision whole-genome 3D reconstruction from extremely sparse single-cell Hi-C data. SCW outperforms existing tools in structural accuracy and robustly maintains intra/inter-chromosomal contacts. Its versatility is validated across diverse cell types.

Topics & Keywords

Single-cell and spatial transcriptomics Genomics and Chromatin Dynamics Cell Image Analysis Techniques

Publication Details

Published in: BMC Bioinformatics

DOI: 10.1186/s12859-026-06421-3

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SCW: building the whole-genome 3D structures based on extremely sparse single-cell Hi-C data

Authors

Abstract

Topics & Keywords

Publication Details