Performance of Circulating Inflammatory Biomarkers and Krebs von den Lungen 6 for Predicting Progressive Pulmonary Fibrosis in Patients With Systemic Sclerosis–Associated Interstitial Lung Disease

Baseline KL-6 and CRP values identify distinct subsets of SSc-ILD patients. Elevated baseline KL-6 levels and a significant rise over the subsequent six months are associated with an increased risk of PPF, supporting their potential as prognostic biomarkers.