Sphingosine-1-phosphate – sphinganine-1-phosphate Imbalance Drives Airway Hyperreactivity

20260 citationsJournal Articlegreen Open Access

Authors

Andrea Heras Barros · Cornell University

Tilla S. Worgall · Columbia University Irving Medical Center

Jose Perez-Zoghbi · Columbia University Irving Medical Center

Abstract

An imbalance between sphingosine-1-phosphate and sphinganine-1-phosphate links the asthma risk locus 17q21 to airway hyperreactivity and reveals sphingolipid metabolism as a potential therapeutic target.

Topics & Keywords

Sphingolipid Metabolism and Signaling Asthma and respiratory diseases Immune Response and Inflammation

Publication Details

Published in: medRxiv

DOI: 10.64898/2026.03.15.26348448

Field-Weighted Citation Impact: 0.00

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Sphingosine-1-phosphate – sphinganine-1-phosphate Imbalance Drives Airway Hyperreactivity

Authors

Abstract

Topics & Keywords

Publication Details