Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study

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Authors

Yulu Zheng · Vanderbilt University Medical Center

Jae Jeong Yang · University of Florida Health

Deepak Ramchandra Gupta · Vanderbilt University Medical Center

David M. Herrington · Wake Forest University

Bing Yu · University of Texas Health Science Center at Dallas

Ngoc Quynh H. Nguyen · University of Texas Health Science Center at Dallas

Rui Pinto

Abstract

We identified and validated circulating gut microbial metabolites associated with incident CHD across diverse populations. Our findings offer novel epidemiological evidence on the importance of gut microbial metabolism in CHD development and highlight specific metabolites to prioritize for mechanistic investigation, biomarker validation, and therapeutic development.

Topics & Keywords

Gut microbiota and health Metabolomics and Mass Spectrometry Studies Cardiovascular Health and Risk Factors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 23, Issue 3, pp. e1004750-e1004750

DOI: 10.1371/journal.pmed.1004750

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