Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

ABSTRACT The global threat of antimicrobial resistance (AMR) to public health, especially in the animal ecosystems, is alarming. This review focuses on how antimicrobial use in aquaculture and livestock contributes to the emergence and spread of AMR on the basis of a One Health (OH) approach. Aquaculture and livestock are essential for meeting the global food demand. However, the use of antimicrobials to manage diseases and promote growth has contributed to the menace of AMR in human and environmental health. We suggest that an integrated approach to AMR management could be achieved by applying OH, which recognizes the common existence and interconnectivity between human, animal, and environmental health. It highlights sustainable actions, international guidelines, and even cross‐sectoral collaboration. These are demonstrated through case studies of existing solutions from various regions, offering models that can be adapted globally. The review concludes with recommendations regarding the stewardship of antimicrobials, regulatory changes, and surveillance improvements to address the growing global threat that AMR poses.