PIEZO1 regulates smooth muscle cell plasticity by integrating mechanical stretch with glycolytic metabolism

20261 citationsJournal Article

Authors

Yapeng Cao · First Affiliated Hospital of Xi'an Jiaotong University

Liran Xu · First Affiliated Hospital of Xi'an Jiaotong University

Meng Zhang · First Affiliated Hospital of Xi'an Jiaotong University

Ailing Su · First Affiliated Hospital of Xi'an Jiaotong University

Siyu Wang · First Affiliated Hospital of Xi'an Jiaotong University

Ting Li · First Affiliated Hospital of Xi'an Jiaotong University

Abstract

Our study reveals that PIEZO1-mediated mechano-metabolic coupling contributes to PASMCs plasticity. This discovery identified an intrinsic mechanism that integrates mechanical stretch with cellular glycolysis during pulmonary vascular remodeling.

Topics & Keywords

Erythrocyte Function and Pathophysiology Blood properties and coagulation Cellular Mechanics and Interactions

Publication Details

Published in: Cardiovascular Research

DOI: 10.1093/cvr/cvag058

Field-Weighted Citation Impact: 32.84

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PIEZO1 regulates smooth muscle cell plasticity by integrating mechanical stretch with glycolytic metabolism

Authors

Abstract

Topics & Keywords

Publication Details