Thyroid function and depression among adolescents: a cross-sectional study exploring sex-based differences

20260 citationsJournal Articlegold Open Access

Authors

Shuwen Xi · Zhejiang Chinese Medical University

Xudong Wu · Second Affiliated Hospital of Zhejiang University

Z. F. Yu · Zhejiang Chinese Medical University

Yinyan Ge · Zhejiang Chinese Medical University

Xinyi Cao · Zhejiang Chinese Medical University

Shengnan Ma · Zhejiang Chinese Medical University

Yuanchu Li

Abstract

Thyroid dysfunction is associated with adolescent MDD in a sex-specific manner. A logistic regression model incorporating both thyroid and sex hormones showed improved classification accuracy. Importantly, testosterone was found to moderate the relationship between T3 and depression severity. These findings suggest that assessing thyroid function alongside sex hormone levels may enhance risk stratification in adolescent MDD.

Topics & Keywords

Thyroid Disorders and Treatments Stress Responses and Cortisol Hormonal and reproductive studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PeerJ

Volume 14, pp. e20983-e20983

DOI: 10.7717/peerj.20983

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