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Pharmacotherapeutics is an essential subject in pharmacy education that deals with the rational and effective use of medicines in the prevention and treatment of diseases. The subject integrates knowledge from pharmacology, pathophysiology, and clinical practice to ensure safe and effective drug therapy for patients. The present book, “A Textbook of Pharmacotherapeutics”, has been prepared especially for the students of Diploma in Pharmacy (D. Pharm) Second Year as per the latest syllabus prescribed by the Pharmacy Council of India (PCI) under Education Regulations 2020 (Course Code: ER20-24T). The objective of this book is to provide a clear and comprehensive understanding of the etiopathogenesis, clinical manifestations, and management of common diseases, along with the principles of rational drug therapy and patient care. The PCI syllabus emphasizes understanding disease conditions, planning appropriate therapeutic interventions, and promoting the quality use of medicines in healthcare practice. This textbook has been written in a simple, student-friendly language to help learners grasp the fundamental concepts of pharmacotherapeutics easily. The chapters are arranged systematically according to the prescribed syllabus and include important topics such as rational use of medicines, evidence-based medicine, and the pharmacological as well as non-pharmacological management of various diseases affecting different body systems such as cardiovascular, respiratory, endocrine, gastrointestinal, and central nervous systems. Special emphasis has been given to the clinical aspects of drug therapy, including therapeutic objectives, drug selection, dosage considerations, monitoring of therapy, and patient counselling. Tables, diagrams, and key points have been included wherever necessary to make the subject more understandable and useful for examination preparation as well as practical application in pharmacy practice. The authors sincerely hope that this book will serve as a useful guide for D. Pharm students, teachers, and pharmacy professionals, helping them develop a strong foundation in pharmacotherapeutics and rational drug use. Every effort has been made to ensure the accuracy of the content; however, suggestions and constructive criticism from readers will be highly appreciated for improving future editions of this book.