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Objective: The present study aimed to compare the variation in lipid profiles between patients with subclinical and clinicalhypothyroidism and their correlation with BMI.Methodology: A cross-sectional study carried out on 120 patients (aged 20-60 years) in the Department of Medicine,Pakistan Institute of Medical Science, Islamabad from December 2024 to September 2025. All the patients were categorizedinto three groups; Group-I euthyroid controls (n=40), Group-II subclinical hypothyroidism (n=40), and clinical hypothyroidism(n=40). Blood sample was taken and analyzed for lipid profiles and thyroid functions. Lipid profiles, Thyroidfunction tests, and body mass index (BMI) recorded for each individual. SPSS v28 used for statistical analysis.Results: Of the total 120 patients, there were 18 (15%) male and 102 (85%) female. The overall mean age (years) andBMI (Kg/m2) were 29.88±5.89 and 29.68 (25-34), respectively. Both hypothyroid groups showed higher levels of lipidprofiles compared to euthyroid controls (p<0.01), with the clinical hypothyroid group showing the highest levels. LowerHDL-C levels observed in hypothyroid groups, but the difference was not statistically significant. Lipid profile and bodymass index showed a positive correlation in both hypothyroid groups, especially in clinical group.Conclusion: The present study observed that increased body mass index and variations in lipid profile in hypothyroidismare established risk factors. Subclinical hypothyroidism exhibits lower BMI and dyslipidemia than clinical hypothyroidism,underling the routine BMI monitoring and lipid profile measurement to manage cardiovascular disease risk at earliest. Keywords: Hypothyroidism, Subclinical Hypothyroidism, Lipid Profile, Body Mass Index, Dyslipidemia, CardiovascularRisk.