Imaging and tracking of clinical proton beam delivery with miniaturized stack telescope Timepix3: feasibility study ofquality assurance for medical proton therapy

Abstract We investigate the feasibility to provide a new technique for non-invasive quality assurance (QA) in clinical proton therapy using a compact stack telescope of Timepix3 (TPX3) detectors. The approach relies on detecting protons scattered at the treatment nozzle and in air downstream of the isocenter, enabling beam monitoring without interfering with patient irradiation. A dual-layer silicon TPX3 telescope was deployed in the fixed beam treatment room at the Proton Therapy Center (PTC) in Prague. Coincidence tracking of scattered protons enabled reconstruction of the therapeutic beam spot by back-plane projection. These results demonstrate the feasibility of a non-invasive QA method based on pixel detectors, highlighting its potential for integration into clinical workflows and its implications for improving proton therapy QA processes.