Application of the integral thrombodynamics method in clinical practice: a systematic review of publications

In laboratory diagnostics of the hemostatic system, two types of tests are used: local (point-ofcare) and integral assays. Local tests are insufficiently sensitive to hypercoagulable states, whereas integral tests allow assessment of thrombotic risk in various pathological conditions and may become an important tool for diagnosing hypercoagulation. However, significant challenges complicate the routine clinical use of integral assays. With the growing number of publications devoted to the application of the thrombodynamics method in different medical fields, there is a need to systematize the accumulated data regarding its clinical use. To perform a systematic review of publications in order to evaluate publication activity in clinical journals devoted to the use of the thrombodynamics method in clinical practice.The systematic review was conducted in accordance with PRISMA principles. Publications from 2015 to 2025 were searched in international databases (PubMed, Web of Science, Scopus) and Russian scientific electronic libraries (CyberLeninka, eLibrary). Additional manual searches were performed using reference lists of identified articles and materials available at: https://gemakor.ru/specialistam/nauchnye-publikatsii/.Retrospective, prospective observational, randomized, and non-randomized studies including ≥20 patients in which the thrombodynamics test was used to assess thrombotic risk and monitor antithrombotic therapy were included. Case reports and review articles were excluded.Analysis of the publications revealed the absence of scientific articles dedicated to evaluating and presenting the analytical characteristics of the thrombodynamics method, quality control issues, and the influence of pre-analytical factors in real clinical practice, which may lead to unreliable results.The conducted systematic review demonstrated that the thrombodynamics test represents a valuable complement to standard hemostasis assessment in a wide range of clinical situations. In all included studies, its use allowed identification of increased thrombotic readiness. Implementation of this test in clinical practice, supported by further research, may improve the effectiveness of prevention and treatment of thromboembolic complications by enabling a more personalized and evidence-based approach to prescribing antithrombotic therapy, provided that methodological requirements and quality control standards are strictly followed.