The use of «short» modes for steam sterilization of glass containers in the production of immunobiological preparations

Modern automatic steam sterilizers make it possible to implement «short» sterilization modes. The use of such modes is effective for products of simple geometric shape with a smooth surface without internal channels. In the manufacture of medicines and medical products, the Russian Anti-Plague Institute Microb of Rospotrebnadzor uses reusable glass bottles, which are sealed with cotton-gauze stoppers and sterilized at a temperature of 132 ° C for 20 minutes. The purpose of the work was to select a material for replacing cotton-gauze plugs and to confirm the possibility of using a «short» sterilization mode. Packaging material for sterilization of medical devices has been selected for the manufacture of paper caps on the neck of bottles. Experimentally, physical, chemical and biological methods have confirmed the necessary temperature values and sterility inside the bottle container during sterilization at a temperature of 134 ° C for 7 minutes. The advantage of this mode is the reduction of the sterilization cycle time compared to the previously used one and the absence of the need to use cotton-gauze plugs. The results of the experimental work will serve as the basis for the validation of the selected sterilization regime and its introduction into production practice. Given the identity of the composition and characteristics of packaging materials for sterilization from different manufacturers, their use is also possible for bottle capping. Keywords: steam sterilization, «short» sterilization modes, sterilization of medical products, packaging paper for sterilization.