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<h3>Background and Importance</h3> In 2022–2023, an analysis of hospital prescriptions executed in community pharmacies for dressings revealed non-compliance in prescribing and dispensing, leading to a 31% overspending for the French National Health Insurance (FNHI – l’Assurance Maladie). To enhance practice and optimise costs, Standardised Prescriptions (SP) for dressings–covering sutured wounds, dermabrasions, and burns–were implemented in the Emergency Department. <h3>Aim and Objectives</h3> To assess the impact of implementing SP in the Emergency Department on prescription and dispensing compliance, as well as on overspending. <h3>Material and Methods</h3> A retrospective comparative study was conducted. Thirty prescriptions from 2023 (before SP = group 1) and thirty prescriptions from 2025 (after SP = group 2) were provided by the FNHI, along with their billing data. Thirteen criteria from the PREDISPAD<sup>1</sup> methodology and three clinical criteria were analysed. A statistical analysis of Non-Compliances (NC) and overspending using the Z-test for the difference between two means in large independent samples (n ≥ 30) was performed. <h3>Results</h3> The mean number of Prescription Non-Compliances (PNC) was 5.67 (±2.71) for group 1 (n = 30) versus 2.2 (±2.78) for group 2 (n = 30). The mean number of Dispensing Non-Compliances (DNC) was 1.8 (±1.58) for group 1 and 0.67 (±1.09) for group 2. The mean Total Overspending (TO) per prescription was €23.17 (±30.7) in group 1 versus €6.94 (±12.3) in group 2. In group 1, Prescription Overspending (PO) and Dispensing Overspending (DO) averaged €13.94 (±19.93) and €3.57 (±11.2), compared with €4.58 (±10.99) and €1.12 (±3.81) in group 2. At a 5% significance level, differences between the groups were significant for overall NC, TO, and PO, but not for DO. <h3>Conclusion and Relevance</h3> The introduction of SP in the Emergency Department significantly reduced PO and PNC, underscoring the value of standardised prescribing in improving efficiency and reducing unnecessary costs. The absence of a significant effect on DO may be attributed to the awareness campaign initiated by the FNHI in collaboration with community pharmacies since 2022, which likely minimised baseline dispensing variability. Future perspectives should explore the implementation of SP in surgical departments, where similar benefits in cost control and practice standardisation may be expected. <h3>References and/or Acknowledgements</h3> 1. Thomelin L. Etude PREDISPAD. 2022. 〈dumas-03831075〉 <h3>Conflict of Interest</h3> No conflict of interest