Phospholipid Glutathione Peroxidase Overexpression Mitigates Cancer Cachexia by Protecting Muscle Mass and Lowering Inflammation

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Authors

Elizabeth S. Duggan · Oklahoma Medical Research Foundation

Jordan D. Fuqua · Oklahoma Medical Research Foundation

Bo Hagy · Oklahoma Medical Research Foundation

Constantin Georgescu · Oklahoma Medical Research Foundation

Benjamin F. Miller · Oklahoma Medical Research Foundation

Holly Van Remmen · Oklahoma Medical Research Foundation

Jacob L. Brown

Abstract

Our results show that GPx4 overexpression protected muscle mass and mitochondrial respiration in tumour-bearing mice, possibly by reducing muscle inflammation. Future studies will explore the potential mechanisms for the protective effect of GPx4 in cancer cachexia.

Topics & Keywords

Muscle Physiology and Disorders Exercise and Physiological Responses Nutrition and Health in Aging

Publication Details

Published in: Journal of Cachexia Sarcopenia and Muscle

Volume 17, Issue 2, pp. e70255-e70255

DOI: 10.1002/jcsm.70255

Field-Weighted Citation Impact: 0.00

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Phospholipid Glutathione Peroxidase Overexpression Mitigates Cancer Cachexia by Protecting Muscle Mass and Lowering Inflammation

Authors

Abstract

Topics & Keywords

Publication Details