Inside Front Cover: On the Discorhabdins Leading to the Aleutianamine Ring System: A One‐Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology

The acid-catalyzed conversion of 3-dihydrodiscorhabdin B through a thiocarbenium iminium dication to aleutianamine, a potent cytotoxic pyrroloiminoquinone alkaloid natural product, greatly increases the recovery of aleutianamine from the marine invertebrate Latrunculia spp. found in the cold, deep ocean along the Aleutian Archipelago. This transformation will help provide the material necessary for its preclinical development. More in Communication (e7864883), Cody F. Dickinson, Mark T. Hamann, and co-workers.