Non-linear age-related change in human Interleukin-11 and the receptor subunit alpha DNA methylation

The observed inverse U-shaped DNAm patterns in the <i>IL11</i> and <i>IL1</i>1RA suggest non-linear age-related regulation that may influence IL-11 expression and sensitivity. These findings indicate that IL-11 may have different roles across life stages and suggest that therapeutic interventions targeting IL-11 should consider age-specific effects.