Mechanisms Underlying Reduced Peak Oxygen Uptake in Older Long-Term Breast Cancer Survivors

20260 citationsJournal Articlediamond Open Access

Authors

Stephen Foulkes · St Vincents Institute of Medical Research

Edith Pituskin · University of Alberta

Thomas McMurtry · University of Alberta

Rachel J. Skow · University of Alberta

Justin Grenier · University of Alberta

Nathan R. Weeldreyer · University of Alberta

Corey R. Tomczak ·

Abstract

Compared to CON, older, long-term BCS display lower VO2peak, and blunted SV during exertion. The prognostic links between VO2peak and future cardiovascular disease suggests decreased VO2peak may be an underappreciated risk factor in older long-term BCS.

Topics & Keywords

Chemotherapy-induced cardiotoxicity and mitigation Antioxidant Activity and Oxidative Stress Metabolism, Diabetes, and Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JACC Advances

DOI: 10.1016/j.jacadv.2026.102610

Field-Weighted Citation Impact: 0.00