Immunogenetic Architecture of Chronic Lymphocytic Leukemia at Early Stage: Insights from the O-CLL1 Cohort

20260 citationsJournal Articlegold Open Access

Authors

Davide Bagnara · University of Genoa

Andrea Nicola Mazzarello · Azienda Ospedaliera S.Maria

Monica Colombo · Azienda Ospedaliera S.Maria

Ennio Nano · Azienda Ospedaliera S.Maria

Niccolò Cardente · University of Oslo

Fabiana Ferrero · Azienda Ospedaliera S.Maria

Nadia Bertola ·

Abstract

Early-diagnosis CLL displays a biased IGHV repertoire with stereotyped configurations characteristic of CLL, including subsets that are rare in the normal B-cell repertoire. These findings support a central role for antigen-driven selection in shaping CLL evolution.

Topics & Keywords

Chronic Lymphocytic Leukemia Research Phagocytosis and Immune Regulation T-cell and B-cell Immunology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Antibodies

Volume 15, Issue 2, pp. 25-25

DOI: 10.3390/antib15020025

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