Therapeutically Targetable Mutational Landscape of Anaplastic Thyroid Cancer

20260 citationsJournal Article

Authors

Murtaza Qazi · Lankenau Medical Center

Muhammad Ahsan · Hospital of the University of Pennsylvania

Talar Telvizian · Lankenau Medical Center

Samuel Laiacona · Lankenau Medical Center

Nadir Ahmad · Cooper University Hospital

T. McHugh · Lankenau Medical Center

Abstract

Somatic PGVs in potentially targetable pathways were found in 72% of ATC tumors. Given the aggressiveness of ATC and the limited efficacy of current treatments, these findings support the rationale for biomarker-driven basket trials investigating the efficacy of targeted therapies in this population.

Topics & Keywords

Thyroid Cancer Diagnosis and Treatment Thyroid Disorders and Treatments Protease and Inhibitor Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JCO Precision Oncology

Volume 10, Issue 3, pp. e2500655-e2500655

DOI: 10.1200/po-25-00655

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