Patient-ventilator interaction—Development of a mathematical model of the respiratory center

20260 citationsJournal Articlehybrid Open Access

Authors

Carlotta Hennigs · Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering

Franziska Bilda · Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering

Helene Selpien · University Hospital Schleswig-Holstein

Tjorben Lerg · Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering

Männel Georg · Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering

Tobias Becher · University Hospital Schleswig-Holstein

Abstract

This respiratory center model provides a robust tool for investigating respiratory control, testing ventilator strategies, and supporting the development of intelligent ventilation approaches, including in silico clinical trials. Its ability to reproduce both normal and pathological ventilatory patterns underscores its potential for translational and clinical research applications.

Topics & Keywords

Respiratory Support and Mechanisms Neuroscience of respiration and sleep Mechanical Circulatory Support Devices

Publication Details

Published in: Computer Methods and Programs in Biomedicine

Volume 280, pp. 109329-109329

DOI: 10.1016/j.cmpb.2026.109329

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Patient-ventilator interaction—Development of a mathematical model of the respiratory center

Authors

Abstract

Topics & Keywords

Publication Details