Spatial remodeling of the tumor immune microenvironment in hepatocellular carcinoma with cirrhosis driven by Treg-CD8⁺T cell crosstalk via the SPP1-ITGA4 axis

20260 citationsJournal Articlegold Open Access

Authors

Dongdong Xue · Second Military Medical University

Xinyao Qiu · Fudan University Shanghai Cancer Center

Meiyu Bao · Second Military Medical University

Danjun Song · Zhejiang Cancer Hospital

Yu Lin · Harbin Medical University

Jinxia Bao · Model Animal Research Center

Jianmin Wu ·

Abstract

In conclusion, CirrHCC promotes a spatially organized Treg-CD8T_CD107a⁺ suppressive niche that constrains CD8⁺ T cell effector function in HCC, with SPP1-ITGA4 emerging as a potential mediating pathway.

Topics & Keywords

Single-cell and spatial transcriptomics Cancer Immunotherapy and Biomarkers Ferroptosis and cancer prognosis

Publication Details

Published in: Translational Oncology

Volume 67, pp. 102734-102734

DOI: 10.1016/j.tranon.2026.102734

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Spatial remodeling of the tumor immune microenvironment in hepatocellular carcinoma with cirrhosis driven by Treg-CD8⁺T cell crosstalk via the SPP1-ITGA4 axis

Authors

Abstract

Topics & Keywords

Publication Details