Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization

20261 citationsJournal Articlegold Open Access

Authors

Elisabeth Aiton · At Bristol

Nancy McBride · University of Bristol

Gemma L. Clayton · University of Bristol

Ana Gonçalves Soares · University of Bristol

Tom A. Bond · University of Bristol

Qun Yang · Shanghai Jiao Tong University

Charikleia Chatzigeorgiou ·

Abstract

We observed higher genetic liability to Hashimoto's thyroiditis, type 1 diabetes, and rheumatic conditions causes increased risk of adverse pregnancy outcomes. Further research is warranted to explore the immune mechanisms underlying these relationships, and identify targets for prevention.

Topics & Keywords

Genetic Associations and Epidemiology Diabetes and associated disorders Prenatal Screening and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Medicine

DOI: 10.1186/s12916-026-04797-w

Field-Weighted Citation Impact: 32.56