Association of clinical and morphological tumor characteristics with the status of chromosomes 1, 3, and 8 in iris melanoma

20260 citationsJournal Article

Authors

S.V. Saakyan · Helmholtz Moscow Research Institute of Eye Diseases

I.V. Svirina · Helmholtz Moscow Research Institute of Eye Diseases

A.Yu. Tsygankov · Helmholtz Moscow Research Institute of Eye Diseases

V. I. Loginov · Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences

AM Burdennyy · Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences

Abstract

The present study showed for the first time that deletions of the short arms of chromosomes 1 and 8 are detected 2.5 times more frequently, and monosomy of chromosome 3 occurs 1.5 times less frequently in iris melanoma compared to choroidal melanoma. The revealed features confirm the more favorable biological behavior of iris melanomas compared to choroidal melanomas.

Topics & Keywords

Ocular Oncology and Treatments Cutaneous Melanoma Detection and Management Melanoma and MAPK Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Russian Annals of Ophthalmology

Volume 142, Issue 1, pp. 28-28

DOI: 10.17116/oftalma202614201128

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