A comparison of differential DNA methylation analysis methods for continuous outcomes: implications for epigenetic studies

20260 citationsJournal Article

Authors

Abstract

The findings of this study indicate that the choice of differential methylation analysis method impacts CpG-level reproducibility, within chromosome co-location, and predictive accuracy. Overall, limma offers a strong balance of reproducibility and predictive value.

Topics & Keywords

Epigenetics and DNA Methylation Genetic Syndromes and Imprinting Gut microbiota and health

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Epigenomics

DOI: 10.1080/17501911.2026.2645006

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