Next-generation pharmaceutically acceptable vehicles for eye drops (preliminary report)

The eye drop vehicle based on an overloaded pH buffer provides a physiological and significant enhancement of transmucosal and transepithelial transport of cationic substances without inducing ocular tissue damage. This approach may increase drug bioavailability, reduce the required initial dose of active components in dosage forms, decrease toxic burden, and eliminate the need for toxic permeability enhancers in ophthalmic formulations.