Search for a command to run...
The therapeutic potential of natural nanoformulations is further exemplified in hepatic disease management. In the work of Hu M. et al., "Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism," co-assembled nanocrystals composed of ursolic acid and α-tocopherol succinate demonstrated enhanced dissolution, improved bioavailability, and restoration of liver function in a cholestatic injury model. Mechanistically, the formulation modulated oxidative stress pathways and bile acid metabolism, highlighting the importance of rational nano-design in targeting disease-specific molecular networks. These findings collectively reinforce the role of nanocarriers in enabling synergistic pharmacodynamics and improving treatment outcomes in liver pathology [15,16].Natural nanomedicine also holds promise in regenerative and neurological contexts. The study "Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats" from Ahmadpour Y. et al., investigates a liposomal nanoformulation designed to mitigate oxidative stress following spinal cord injury. Treatment improved sensory-motor function, enhanced antioxidant defenses, and promoted neuronal survival, demonstrating how nano-delivery systems can support neuroprotection and functional recovery. These findings contribute to the growing evidence supporting antioxidant-based nanotherapies in neurological disorders [17,18]. Chronic wound management represents another major translational challenge addressed within this Topic. The review work from Yadav P.S. et al., "Therapies and delivery systems for diabetic wound care: current insights and future directions" discusses current understanding of diabetic wound pathophysiology and examines how nano-enabled delivery systems enhance the therapeutic performance of plant-derived bioactive formulations. By integrating phytochemicals with polymeric or metallic nanocarriers, targeted delivery, antimicrobial action, and tissue regeneration may be improved. The review also contextualizes emerging nano-therapies within ongoing clinical and patent developments, bridging experimental innovation with clinical implementation pathways [19][20][21][22][23].In oncology, natural nanomaterials are increasingly explored for targeted therapy and diagnostic applications. The review from Pandey P. et al., "Biosynthesis of silver nanoparticles from plant extracts: a comprehensive review focused on anticancer therapy" provides an extensive overview of plant-mediated silver nanoparticle synthesis and their emerging roles in cancer detection and treatment. By leveraging phytochemicals as reducing and stabilizing agents, green-synthesized nanoparticles offer a sustainable strategy to enhance selectivity and reduce toxicity compared with conventional treatments. Complementing this perspective, the research article of Cui L. et al., "Plant-derived extracellular nanovesicles: a promising biomedical approach for effective targeting of triple negative breast cancer cells" presents experimental data considering the anticancer activity of Citrus limon-derived extracellular nanovesicles. These vesicles demonstrated cellular uptake, suppression of proliferation and migration, and modulation of PI3K/AKT and MAPK/ERK signaling pathways in triple negative breast cancer models. Overall, both findings highlight the convergence of green chemistry, and nanotechnology, as a promising direction for future therapeutic developments in oncology [24][25][26][27][28][29][30][31][32].Beyond experimental advances, understanding research trajectories is essential for guiding future innovation. The bibliometric analysis "Unveiling the dynamic trends of plant-derived exosome nanovesicles-based theranostics: through bibliometric and visualized analysis" from Cao S. et al., maps the years of scientific activity in plant-derived nanovesicle research. By identifying dominant research themes, contributing institutions, and emerging hotspots, this work provides a strategic overview of the field's evolution and highlights opportunities for interdisciplinary collaboration and translational advancement [33][34][35][36][37].Across these contributions, several cross-cutting themes emerge. First, nanoencapsulation consistently enhances pharmacokinetic performance and therapeutic stability of natural compounds, reinforcing the importance of formulation science in maximizing biological activity [38][39][40][41][42]. Second, sustainability and biosafety remain essential considerations, particularly in the context of green synthesis and long-term biological interactions of nanomaterials [43][44][45][46]. Third, mechanistic understanding linking nanostructure to biological function is increasingly emphasized, supporting rational design strategies for targeted therapy [47][48][49][50][51]. Finally, translational progress will depend on integrating predictive modeling, standardized characterization, and regulatory frameworks to bridge preclinical success with clinical application [52][53][54][55].In summary, this Research Topic highlights the extent and momentum of natural-based nanomedicine research, spanning fundamental formulation science to disease-specific therapeutic applications. The collected works demonstrate that natural nano-formulations can enhance drug performance, modulate disease pathways, and offer sustainable alternatives to conventional therapies. Continued interdisciplinary collaboration and rigorous translational strategies will be essential to fully realize the clinical potential of these emerging pharmacological technologies.