OpenScientist: evaluating an open agentic AI co-scientist to accelerate biomedical discovery

20260 citationsJournal Articlegreen Open Access

Authors

Kaleigh F. Roberts · Washington University in St. Louis

Zachary B. Abrams · Washington University in St. Louis

Luca Cappelletti · University of Fribourg

Mahdi Moqri · Harvard University

Nicholas Heugel · Washington University in St. Louis

J. Harry Caufield · Lawrence Berkeley National Laboratory

Mathieu Bourdenx

Abstract

OpenScientist demonstrates that open, auditable, agentic AI can support real-world clinical research by generating hypotheses, executing analyses, and discovering insights from complex datasets.

Topics & Keywords

Single-cell and spatial transcriptomics Cancer Genomics and Diagnostics Ferroptosis and cancer prognosis

UN Sustainable Development Goals

Quality Education

Publication Details

Published in: medRxiv

DOI: 10.64898/2026.03.15.26348338

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