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<h3>Background and Importance</h3> Voriconazole can be administered intravitreally to treat fungal endophthalmitis. To our knowledge, there is no licensed, ready-to-use antifungal formulation for intravitreal administration on the market. To address this unmet need, hospital preparations can be compounded in syringes, commonly made of polypropylene. In the absence of stability data for this container type, we conducted a stability study in polypropylene syringes. <h3>Aim and Objectives</h3> To evaluate the physicochemical stability of voriconazole at 1 mg/mL in polypropylene syringes, diluted in 0.9% sodium chloride (NaCl), after preparation and after 1, 3, 7, 14, and 28 days of storage at 2–8 °C, protected from light. <h3>Material and Methods</h3> Three 60 mL polypropylene syringes containing voriconazole at 1 mg/mL in 0.9% NaCl were prepared. Chemical stability was assessed by pH measurement and high-performance liquid chromatography validated according to the International Conference on Harmonisation Q2(R1). The solution was chemically stable if it retained more than 90% of its initial concentration, with the appearance of any degradation products monitored, and if the pH variation was less than one unit. Physical stability was evaluated by visual and subvisual inspection using a particle counter according to European Pharmacopoeia monographs 2.9.20 and 2.9.19. Solutions were considered physically stable if no precipitate, aggregation or colour change was observed, and if each sample contained fewer than 6000 particles of 10 µm and fewer than 600 particles of 25 µm. <h3>Results</h3> After 28 days, voriconazole concentrations remained between 96.3% and 102.2% of the initial value. pH variations ranged from −0.21 to +0.58 compared with baseline, confirming chemical stability. No visual changes were observed. Subvisible particle counts remained within limits, with maxima of 2540 particles of 10 µm (at day 1) and 160 particles of 25 µm (at day 28), demonstrating physical stability. <h3>Conclusion and Relevance</h3> Voriconazole at 1 mg/mL in polypropylene syringes diluted in 0.9% NaCl is physicochemically stable for 28 days when stored at 2–8 °C, protected from light. From a stability perspective, these findings support the hospital preparation of voriconazole in polypropylene syringes for intravitreal injection, and the 28-day stability enables advance preparation, ensuring rapid availability for patients. <h3>Conflict of Interest</h3> No conflict of interest