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Introduction Human development is situated within relational contexts that commence before birth and persist throughout the lifespan. Relationships influence emotional, cognitive, and social trajectories, spanning from prenatal bonding and maternal-fetal attachment to adult partnerships and intergenerational caregiving. Objectives The objectives of this paper are to review empirical evidence regarding the influence of relationships on developmental outcomes from prenatal stages to old age, analyze the mechanisms connecting attachment and relational quality to wellbeing throughout the lifespan, and identify areas of continuity, change, and potential intervention in relational development. Methodology This study, following the PRISMA 2020 guidelines, employed a systematic review combined with domain-specific meta-analysis and structured narrative synthesis to conduct a comprehensive analysis of peer-reviewed articles published between 2014 and 2024 in the PubMed, Embase, Web of Science, and Scopus using predefined Boolean search terms related to prenatal bonding, early attachment (prenatal → infancy/early childhood), and lifespan relationships. Quantitative meta-analysis was performed only where methodological and conceptual comparability was established; otherwise, descriptive meta-analysis was employed to encompass the breadth and depth of contemporary knowledge. Findings Evidence suggests that maternal stress and mental conditions during pregnancy influence fetal development and establish the foundation for postnatal attachment. Secure attachment throughout infancy promotes socio-emotional competence, but insecure attachment is associated with an increased risk of psychopathology. In early childhood, attachment affects autonomy, exploration, and cultural manifestations of caregiving. In middle childhood, peer relationships and teacher support are crucial, but exclusion and bullying detrimentally affect psychological wellbeing. Adolescence entails the development of identity, the impact of peer influence, and the negotiation of autonomy within parent-child relationships. In adulthood, attachment styles are evident in romantic relationships, marriage, and parenting, influencing family stability. Conclusion relationships serve as both a protective resource and a transforming influence in human development. Attachment-informed, culturally sensitive, and lifespan-oriented policies and interventions can bolster resilience, boost mental health, and elevate quality of life across generations.