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This study analyzes approaches to the diagnosis and treatment of mammary cancer in animals. The authors examined carcinogenesis using small domestic animals as a study subject to ensure adherence to bioethical principles and to enhance the statistical validity of the results obtained in a clinical setting using modern equipment and data recording in electronic medical records. It should be noted that the incidence of malignant neoplasms in the mammary gland depends on the individual characteristics of the animals, as well as the duration of exposure and the type of carcinogen. Since the development of malignant neoplasms is a significant issue not only for pet owners but also for veterinarians treating farm animals, the chosen research topic is relevant. Mammary cancer is widespread among food-producing animals, causing significant losses in both dairy and meat production due to the culling of carcasses or parts affected by tumors, and is a frequent cause of disruption to the normal reproduction of healthy livestock, including the feeding of young animals. One of the most common types of malignant tumors in farm and domestic animals, arising from carcinogenesis, is mammary cancer. Comparing data on the etiology, pathogenesis, clinical presentation, and morphology of mammary tumors in various animal species is an extremely important process for the development of comparative oncology. The obtained data can be used to diagnose and treat mammary cancer in various animal species.