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Physician well-being is a multidimensional concept encompassing physical, mental, and social health; life satisfaction; and purpose. Broader than wellness, which focuses on health behaviors, well-being and its importance to patient safety and care quality are well-documented, with poor clinician well-being contributing to burnout, medical errors, and diminished outcomes. Experienced by physicians at higher rates than other professionals, burnout is driven by chronic workplace stress and is amplified by cultural norms in medicine of stoicism and perfectionism. This, in turn, erodes resilience and meaning in medicine. In obstetrics and gynecology, these challenges are compounded by legislative interference and systemic practice pressures, prompting the American College of Obstetricians & Gynecologists (ACOG) to launch a comprehensive National Well-Being Program. Grounded in the Stanford Model of Professional Fulfillment and expanded to meet specialty-specific needs, the program spans six domains: personal wellness, workplace belonging, peer support, practice efficiency, social engagement, and the engagement in arts, as outlined in the ACOG Well-Being Wheel. Program development follows a structured, evidence-informed strategy: cataloging existing resources, conducting gap analyses, and piloting targeted interventions. Foundational program initiatives include the ACOG Well-Being website, the National Well-Being Delegation, and the peer-support program, with future phases focused on scaling programs, measuring effects, and linking physician well-being to patient outcomes and workforce sustainability.