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Abstract This second addition of High-Quality Psychosocial Interventions Research, From Conception to Piloting to Population Based Trials is a comprehensive guide for junior and investigators new to psychosocial interventions who wish to conduct clinical trials on psychosocial treatments. This book offers practical guidance on the ethical and efficient conduct of these studies and covers a range of topics from including how to assemble and manage research teams, ethical considerations, and how to run clinical trials of psychosocial interventions, from proof of concept to pragmatic effectiveness. This updated edition builds on the first by discussing alternative trial designs and how to conduct safe and effective remote or digital clinical research. It is suitable for investigators at all career stages. Students and junior faculty will find it a valuable step-by-step resource for planning and executing their research, while more experienced researchers—particularly those new to psychosocial interventions or effectiveness research—will find selected chapters especially useful. Each chapter covers ethical management of psychosocial intervention research, considerations for diversity and health disparities, example data reporting and sharing tools, sample forms for partnering with industry, and sample budgets for the various types of clinical trials.