Molecular and cellular consequences of tumour-autonomous IL-6 signalling in intrahepatic cholangiocarcinoma

20260 citationsJournal Articlehybrid Open Access

Authors

Virag Gehl · University of Copenhagen

Colm J. O’Rourke · University of Copenhagen

Martin Cornillet · Karolinska Institutet

Orestis Nousias · University of Copenhagen

Achilleas Fardellas · Karolinska Institutet

Supaporn Yangngam · University of Copenhagen

Magdalena Rogalska ·

Abstract

These findings uncover a multifaceted role for IL-6 in shaping tumour-intrinsic, microenvironmental and macroenvironmental features, revealing novel molecular mechanisms and potential therapeutic vulnerabilities in iCCA.

Topics & Keywords

Cholangiocarcinoma and Gallbladder Cancer Studies Chemokine receptors and signaling Cytokine Signaling Pathways and Interactions

Publication Details

Published in: Gut

DOI: 10.1136/gutjnl-2025-337579

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Molecular and cellular consequences of tumour-autonomous IL-6 signalling in intrahepatic cholangiocarcinoma

Authors

Abstract

Topics & Keywords

Publication Details