[The prostate biopsy during the follow-up of a cohort of 400,000 asymptomatic men undergoing PSA testing in the Agency for Health Protection of the Metropolitan Area of Milan].

among residents of the ATS Milano area, a PSA level equal to or greater than 3 ng/mL identifies an early increased risk of prostate carcinoma. To ensure the timely identification of all clinically significant cases, biopsy should be integrated into a multimodal diagnostic pathway including advanced imaging, which was not always available in the analysed cohort.