GRANULOMATOSUS VARIANT OF ROSACEA: EXPERIENCE OF COMBINED USE OF DRUG THERAPY AND HIGH-ENERGY TECHNOLOGIES

Granulomatous rosacea (GR) is a rare, clinically challenging form of dermatosis characterized by resistance to standard therapy. This work presents the experience of combined treatment in two female patients (aged 36 and 48 years) with clinically diagnosed GR. A comprehensive strategy was applied: systemic isotretinoin (8–16 mg/day), topical 1% metronidazole, and high-energy techniques – intense pulsed light (IPL) in the first patient and microneedling radiofrequency (MRF) in the second. The course included three procedures at 3–4-week intervals. Sustained clinical remission was achieved in both patients: 12 months of follow-up in the first patient (Fig. 2) and 6 months in the second (Fig. 4). The observation confirmed the effective impact on deep inflammatory and vascular components of pathogenesis. The proposed approach is a promising solution for therapy-resistant GR forms.