Danon Disease Diagnosed by Multimodal Imaging

Young men exhibiting myocardial hypertrophy, elevated plasma creatine kinase, pre-excitation on electrocardiography, and/or characteristic late gadolinium enhancement on cardiac magnetic resonance should be evaluated for Danon disease. Multimodal imaging (echocardiography, cardiac magnetic resonance) combined with genetic testing is key to accurate diagnosis. Family screening and genetic counseling are crucial given the X-linked dominant-inheritance pattern.