The role of gene polymorphisms associated with the functioning of the renin-angiotensin system in the development of arterial hypertension and preeclampsia

Hereditary predisposition is one of the risk factors for arterial hypertension. The renin-angiotensin-aldosterone system plays a key role in the pathogenesis of arterial hypertension. Previous studies have shown a correlation between the AGT and AGTR genes and the risk of developing arterial hypertension. The genes of the renin-angiotensin system are considered candidates for predisposition to preeclampsia. In our study, we examined the relationship between arterial hypertension (AH) and polymorphisms of the renin-angiotensin-aldosterone system genes: AGT: 704 T>C, AGT: 521 C>T, AGTR 1: 1166 A>C, and AGTR 2: 1675 G>A, among the European population of Moscow. The presence of the T allele of the AGT gene (T704C) has a protective effect on the development of AH. The CT and TT genotypes of the AGT gene (C 521T) are significantly more common in hypertensive patients, which may indicate a negative effect of the T allele on the development of hypertension. Carrying the CC genotype of the AGTR 1 gene (A1166C) may predispose to hypertension. It has been established that the presence of the G allele and the G allele.