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The increasing concerns over environmental sustainability, insecticide resistance, and human health risks associated with synthetic agrochemical pesticides have led to a growing interest in biopesticides. This chapter explores the potential of peptides, particularly venom-derived peptides, as novel biopesticides for pest management. Venom peptides from species such as spiders, scorpions, and wasps exhibit potent insecticidal properties and have emerged as promising alternatives to traditional insecticides due to their high specificity, biodegradability, and reduced environmental impact. The chapter discusses the discovery and commercialization of venom peptide-based biopesticides, including the first commercial product, SPEAR®, developed by Vestaron Corporation. Additionally, other bioactive peptides, such as Harpin and Trypsin Modulating Oostatic Factor (TMOF), have been explored for their pest control potential. Advances in genetic engineering have further facilitated the expression of insecticidal peptides in plants, enhancing crop protection. Moreover, plant defensins and antifungal peptides offer new strategies for combating fungal pathogens. This chapter provides a comprehensive analysis of venom peptides as a next-generation green chemistry pest management solution, underscoring their potential to revolutionize pest control while minimizing environmental and human health risks. Through continual advances in biotechnological research, venom peptides are poised to play a significant role in the future of sustainable agriculture.