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<h3>Background and Importance</h3> The preparation of radiopharmaceuticals (RPs) is a critical step in their overall workflow and must comply with strict quality and safety standards. As part of a continuous improvement approach to professional practices, we developed an innovative training program based on scenario analysis. <h3>Aim and Objectives</h3> To strengthen the competencies of operators working in the RPs preparation laboratory, ensuring both process safety and optimal preparation quality. <h3>Material and Methods</h3> An interactive training module was designed as a slideshow incorporating an initial knowledge assessment using an online quiz application, with 10 questions (nine multiple- or single-choice and one open-ended). The topics covered included controlled atmosphere areas (CAA) (n = 3), hygiene and personal protective equipment (PPE) (n = 1), good preparation practices (GPP) (n = 3), and radioactivity (n = 3). Videos recorded within the CAA illustrating common errors served as the basis for scenario analysis. During a collective debriefing session, participants identified these errors and received complementary theoretical input covering the same topics. Knowledge reassessment will be performed four weeks after the session, and both the content and format of the training were evaluated using a satisfaction questionnaire. <h3>Results</h3> Two 1 hour sessions were conducted, including eight radiologic technologists (RTs), one pharmacy technician, and one supervisor. Only RT results were analysed. The mean score was 7.5/10 ± 0.67 (range: 6.5–8.7). During debriefing, participants actively identified procedural errors and expressed strong interest in this pedagogical approach. The rates of correct answers were 83% for CAA, 76% for radioactivity, 70% for GPP, and 63% for hygiene/PPE. A detailed comparison of pre- and post-training results will be presented on the poster. Overall, participants rated the content, duration, and format of the session as highly satisfactory. <h3>Conclusion and Relevance</h3> This training successfully increased awareness among operators of Good Preparation Practices, hygiene protocols, and essential safety measures to minimise errors and ensure compliance with procedures. Its interactive format, combined with video-based analysis of real-life scenarios, was particularly well received. To further consolidate this continuous improvement initiative, an audit of GPP compliance and hygiene practices will soon be conducted to assess the training’s practical impact in the workplace. <h3>Conflict of Interest</h3> No conflict of interest