Meta‐diamides: Broflanilide

The insecticide broflanilide is highly active against various insects, including Lepidopteran, Coleopteran, and Thysanopteran species. It is a meta-diamide, a structure generated through significant modification of flubendiamide. Broflanilide is active as an allosteric modulator of insect γ-aminobutyric acid (GABA)-gated chloride channels, with a suggested action site different from conventional GABA-gated chloride channel blockers. This unique action makes broflanilide effective even against strains resistant to fipronil and flubendiamide. in vitro analysis indicates that meta-diamides like broflanilide are selective for insect GABA receptors over mammalian GABA and glycine receptors, highlighting their potential as a targeted insecticide.