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Introduction: Mental disorders, including depression, anxiety, bipolar disorder, and obsessive- compulsive disorder (OCD), significantly impair thoughts, emotions, behaviors, and marital satisfaction, impacting the quality of life. This study evaluated the impact of psychiatric follow-up treatments on marital satisfaction among women with mental disorders in Jiroft city, Iran. Methods: A pre-post intervention study employed convenience sampling to enroll 100 married women diagnosed with depression, anxiety, bipolar disorder, or OCD at psychiatric clinics in Jiroft city in 2024. The Enrich Marital Satisfaction Questionnaire (47 items, Cronbach’s α = 0.95) was administered before and after 3-6 months of pharmacological treatment. Data were analyzed using SPSS version 20. Normality was assessed with the Kolmogorov-Smirnov test, followed by paired ttests to compare pre- and post-treatment scores within each disorder group. Effect sizes (Cohen's d) and 95% confidence intervals (CIs) were calculated to assess the magnitude of the observed changes. Statistical significance was set at P< 0.05. Results: Pharmacological treatment significantly improved marital satisfaction across all disorders (P< 0.01). Mean marital satisfaction scores increased as follows: anxiety disorders (22.89 to 24.45, P< 0.01), depressive disorders (19.83 to 22.89, P< 0.01), bipolar disorders (15.15 to 19.81, P< 0.01), and OCD (16.66 to 22.10, P< 0.01). Higher education levels were associated with greater improvements in the anxiety group, while younger age correlated with better outcomes in the depression group. Conclusion: Psychiatric follow-up treatments significantly enhance marital satisfaction in women with mental disorders. These findings highlight the need for tailored interventions to improve relational outcomes, though further studies with control groups are warranted.