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Introduction: Owing to biological and systemic factors, women face a disproportionate burden of infectious diseases. This short communication introduces a novel integrated framework of reproductive and infectious disease epidemiology to reveal gendered health inequities amplified by the pandem-ic—a previously underexplored issue in global health. Methods: A concise review of peer-reviewed and organizational reports (WHO, UNAIDS, Pub- Med) was conducted between 2015 and 2025 to evaluate the evidence on gender inequity in infectious diseases. Results: The data infers that women experience a higher rate of susceptibility to certain infections due to hormonal imbalance, immune suppression tendency, and anatomical differences. These situations worsened after the COVID-19 pandemic for women. Discussion: The biological and societal vulnerabilities of women make them more susceptible to infectious diseases. These disparities have been further widened after a pandemic like COVID- 19, which deepened the health inequities and need a thorough, equitable, gender-focused healthcare policy and solutions. Conclusion: Future research should focus on collecting gender-separated data and using gendersensitive approaches to ensure fair healthcare solutions. Limitations include a lack of specific sex- and gender-related epidemiological evidence and limited analysis that goes beyond the gender binary. Future prospects include long-term, community-based studies, combining reproductive and infectious disease tracking with better data collection methods, and recruiting more women for clinical trials and leadership roles. Collaborative, gender-aware, and evidencebased policies are crucial for improving health equality worldwide. Tackling these challenges is a vital commitment of the global health community.