Pyflubumide

This chapter outlines the details of the discovery, chemistry, mode of action (MoA), biological profile, and cross-resistance aspects of pyflubumide. The discovery of pyflubumide originated with the following two types of chemical compounds: SDHI fungicides having a carboxamide structure and the novel pesticides flubendiamide and pyrifluquinazon having a heptafluoroiso-propyl group developed by Nihon Nohyaku Co., Ltd. Pyflubumide is highly effective against the globally important polyphagous spider mites, including the species Tetranychus spp. and Panonychus spp. , which suggests that this compound should contribute to agricultural production. Pyflubumide showed excellent activity against field populations of spider mites that had developed resistance to the conventional acaricides. The toxicities of pyflubumide on several beneficial arthropods, including natural enemies. The MoA of these acaricidal carboxamides was expected to be the inhibition of mitochondrial complex II from their structural similarities with SDHI carboxamides.