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Indoxacarb is an oxadiazine insecticide that is highly effective against a broad spectrum of lepidopteran pests along with pests of multiple insect orders. Its high lipophilicity allows for absorbance into the waxy cuticle of leaves contributing to indoxacarb's residual control and rainfastness. In addition to being an excellent crop protection product, it's had good commercial success in the management of home pests including ants, cockroaches, termites, and fleas. Indoxacarb is a proinsecticide requiring bioactivation to the N -decarbomethoxylated metabolite, DCJW, via hydrolytic esterase and amidase metabolism. DCJW exhibits nanomolar potency as a state-dependent inhibitor of the voltage-gated sodium channel (VGSC). Upon binding to the slow-inactivated state VGSCs are blocked with no significant impact on activation or fast inactivation channel kinetics. DCJW binds to the same site as local anesthetics with a differential affinity for insect over mammalian VGSCs. This coupled with differential metabolism between insects and mammals contributes to indoxacarb's excellent mammalian safety.