Monogenic and Polygenic Risk for Kidney Cancer in Two Large Biobanks

20260 citationsJournal Articlehybrid Open Access

Authors

Jun Wei · Center for Genomic Science

Ashley Mulford · Genomic Health (United States)

Zhuqing Shi · Center for Genomic Science

Huy Tran · Center for Genomic Science

Annabelle Ashworth · Center for Genomic Science

S. Lilly Zheng · Center for Genomic Science

Jim Lu ·

Abstract

Many patients with kidney cancer do not carry rare inherited mutations. Our study shows that common genetic factors, captured in a PRS, can also identify high-risk individuals. Combining both rare mutations and common polygenic risks provides a more complete assessment of kidney cancer risk and may aid in earlier screening and prevention.

Topics & Keywords

Renal cell carcinoma treatment Cancer Genomics and Diagnostics Biological Research and Disease Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Urology Oncology

DOI: 10.1016/j.euo.2026.03.004

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