Pyridachlometyl and Other Tubulin Dynamics Modulators

Pyridachlometyl is a multispectrum fungicide with potent activity against various true fungi. This compound belongs to the tubulin dynamics modulator family, which has been extensively investigated by several research teams within the agrochemical industry since the 1990s. Despite the publication of numerous patents and the identification of notable experimental molecules such as BAS600F, only pyridachlometyl is under commercial development in 2023. Tubulin dynamics modulator fungicides are distinct from tubulin polymerization inhibitor fungicides, such as carbendazim, in terms of both their mechanism of action and their binding sites on tubulins. Consequently, tubulin dynamics modulator fungicides are not affected by resistance to tubulin polymerization inhibitor fungicides. Pyridachlometyl is expected to serve as a valuable tool for securing crop yields against destructive crop pathogens that have acquired resistance to existing fungicides.