Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons

20260 citationsJournal Articlegold Open Access

Authors

Konstantina Chanoumidou · University of Crete

Ioanna Zota · University of Crete

Maria Anna Papadopoulou · University of Crete

Chrystalla Konstantinou · University of Crete

Alexandros Tsimpolis · University of Crete

Electra Tsagliotis · Foundation for Research and Technology Hellas

Maria Tziortziou

Abstract

Our findings show that high glucose impairs human dopaminergic neuron survival through activation of the pro-NGF/p75NTR axis and indirect glia-mediated mechanisms. Targeting p75NTR signaling may offer neuroprotective benefits in diabetes-related neurodegeneration, particularly for patients at risk of Parkinson's disease.

Topics & Keywords

Nerve injury and regeneration Nuclear Receptors and Signaling Parkinson's Disease Mechanisms and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stem Cell Research & Therapy

DOI: 10.1186/s13287-026-04965-y

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