TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma

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Authors

Bo Guan · Fuyang City People's Hospital

Haoda Tang · Fuyang Maternity and Child Health Care Hospital

Zhen Yuan · Fuyang Second People's Hospital

Jun Yao · Fuyang Normal University

Di Cui · Fuyang Normal University

Zongyao Hao · Anhui Medical University

Xiaowei Li ·

Abstract

The TRIM21-FBL axis regulates ccRCC progression by modulating PI3K/AKT signaling, providing mechanistic insight and potential therapeutic targets for ribosome biogenesis and oncogenic signaling.

Topics & Keywords

interferon and immune responses Ubiquitin and proteasome pathways Ferroptosis and cancer prognosis

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Cellular and Molecular Life Sciences

Volume 83, Issue 1

DOI: 10.1007/s00018-026-06113-4

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