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Sex-Specific Metabolic Remodelling in Infantile Haemangioma

20260 citationsJournal Articlediamond Open Access

Authors

Infantile Haemangioma (IH) is the most frequent vascular tumour in infants · MP Technologies (United States)

characterised by aberrant angiogenesis in the first year of life with propranolol (β-blocker) being the primary treatment option · MP Technologies (United States)

although the pathogenesis is poorly understood. We performed proteomic profiling of IH patient samples across its three phases– proliferating · MP Technologies (United States)

plateau and involuting in males and females · MP Technologies (United States)

and healthy skin controls · MP Technologies (United States)

with validation by western blot and PCR array.

Topics & Keywords

Teratomas and Epidermoid Cysts Vascular Malformations and Hemangiomas Genetic Syndromes and Imprinting

Publication Details

Published in: Clinical & Experimental Dermatology and Therapies

Volume 11, Issue 1

DOI: 10.29011/2575-8268.100247

Field-Weighted Citation Impact: 0.00

Sex-Specific Metabolic Remodelling in Infantile Haemangioma | Researchclopedia

· MP Technologies (United States)

Bioinformatics revealed differential expression in LXR/RXR activation · MP Technologies (United States)

DHCR24 signalling · MP Technologies (United States)

and mitochondrial dysfunction. Oxidative phosphorylation complexes I and IV were highly expressed in female proliferating IH · MP Technologies (United States)

with increased oxidative stress. Further · MP Technologies (United States)

we validated the regulation of cholesterol homeostasis in IH using PCR array. Proliferation · MP Technologies (United States)

migration and angiogenesis were upregulated in female lesions compared to males · MP Technologies (United States)

possibly explaining the higher severity and incidence in females. · MP Technologies (United States)

In summary · MP Technologies (United States)

we have generated the proteomic landscape of IH in both sexes identifying altered pathways and potential therapeutic targets. · MP Technologies (United States)